Medication Information - Antiplatelets
Henry I. Bussey, Pharm.D., FCCP, FAHA March, 2005
Last Updated: 4/26/2007
Prescribing Information - 2007
BMC Medicine 2006, 4:12. doi:10.1186/1741-7015-4-12. Conclusions: Contrary to recent findings, low dose aspirin is effective and medium dose aspirin did not prove superior for inhibiting platelet aggregation after coronary surgery.
Testing patients for resistance is becoming more common, but it's not clear how useful this information is or what to do with it.
Drug commonly given to heart and stroke patients to reduce plaque buildup (clots).
CVD is a complex and burdensome group of illnesses. Atherothrombosis is a feature common to the most devastating of the CV events. Low-dose aspirin and clopidogrel have been shown to substantially reduce the incidence of vascular events in a variety of patient populations, while simultaneously increasing the risk of major hemorrhage. Thus, it is imperative that these agents be utilized when appropriate, yet monitored closely. Pharmacists can play a crucial role in the management of CVD generally and in the utilization of antiplatelet agents in particular.
The American Journal of Medicine. Volume 120, Issue 1 , January 2007, Pages 1-4.
Is an aspirin a day the right thing for you? It's not as easy a decision as it sounds. Know the benefits and risks first.
November 2004 Antiplatelet agents are drugs which interfere with the ability of platelets to aggregate and form a platelet plug. As antithrombotic agents, they are most useful in clinical states due to arterial vascular disease.
Veins are made up very differently compared to arteries. Veins are thin blood vessels with slow flowing blood. Blood clots that form in veins (deep vein thrombosis, pulmonary embolism) are mainly made up of clotting proteins; platelets do not play a big role in venous clots. Coumadin (= warfarin) is an effective "blood thinner" by preventing the production of clotting factors in the liver, increasing the INR. It is therefore the drug of choice in venous thrombosis. Anti-platelet drugs do not play much of a role in preventing venous clots.
To some degree it does, but it is by far not as effective as warfarin or other blood thinners (anticoagulants).
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