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Antiphospholipid Inner Ear Syndrome

The Laryngoscope Volume 115, Issue 5, pages 879–883, May 2005. Conclusions: These data support the hypothesis that antiphospholipid antibodies are involved in the pathogenesis of some forms of inner ear dysfunction, presumably by causing microthrombus formation in the labyrinthine vasculature. Basic science studies are required to better understand the mechanisms by which antiphospholipid antibodies mediate inner ear dysfunction. Clinical studies to evaluate the efficacy of anticoagulation in this group of patients are also required.

Antiphospholipid Inner Ear Syndrome

The Laryngoscope Volume 115, Issue 5, pages 879–883, May 2005. Conclusions: These data support the hypothesis that antiphospholipid antibodies are involved in the pathogenesis of some forms of inner ear dysfunction, presumably by causing microthrombus formation in the labyrinthine vasculature. Basic science studies are required to better understand the mechanisms by which antiphospholipid antibodies mediate inner ear dysfunction. Clinical studies to evaluate the efficacy of anticoagulation in this group of patients are also required.

The Antiphospholipid Syndrome

TIGC Guidelines

Inferior Vena Cava Filters

TIGC Guidelines. Reduces, but does not eliminate, the risk of symptomatic PE in patients with proximal DVT in the short-term7; Does not prevent small PE; Not proven to reduce PE in the long-term. Large venous collaterals develop around an occluded IVC. Patients have had PE (and fatal PE) after IVC filters (< 5%).; Insertion site thrombosis (up to 40% with femoral approach); No pressure gradient across the filter (unless > 60% of IVC occluded by clot); Little or no thrombogenic potential; High rate of long-term patency (> 95%); No evidence of a decrease in fatal PE; No all-cause mortality reduction; Increase in symptomatic DVT in patients with filters

Antiphospholipid-related chorea

Chorea is a movement disorder which may be associated with immunologic diseases, in particular in the presence of antiphospholipid antibodies (aPL). Choreic movements have been linked to the isolated presence of plasmatic aPL, or to primary or secondary antiphospholipid syndrome. The highest incidence of aPL-related chorea is detected in children and females. The presentation of chorea is usually subacute and the course monophasic. Choreic movements can be focal, unilateral, or generalized. High plasmatic titers of aPL in a choreic patient can suggest the diagnosis of aPL related-chorea; neuroimaging investigation does not provide much additional diagnostic information. The most relevant target of aPL is β2-glycoprotein I, probably responsible for the thrombotic manifestations of antiphospholipid syndrome. Etiology of the movement disorder is not well understood but a neurotoxic effect of aPL has been hypothesized, leading to impaired basal ganglia cell function and development of neuroinflammation. Patients affected by aPL-related chorea have an increased risk of thrombosis and should receive antiplatelet or anticoagulant treatment.


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